Wine on Linux usually works for me, though occasionally there can be issues and tweaking may be required. Typically, I use a separate 32 bit wine prefix for each game, using the "sandbox" setting from winetricks to disconnect it from my normal home directory. Grabbing ffdshow (via ffdshow-tryouts, not winetricks) can be useful too.
However, I haven't tried anything eushully lately (or anything else that hardware-intensive). Recently, retouch.info/ExHIBIT, kirikiri, and other things that don't involve 3D graphics, though some might use 3D hardware for drawing.
