ATM theres no anime/vn that really pops into mind but there are some unique stuff that i can think of in animes for example:
One Piece: Devil Fruits...com'on now, gotta admit, thats pretty freakin weird, and it makes people cant swim? its a sea based setting. UNIQUE
Bakuman: Manga/anime about getting a manga/anime?oh the irony: UNIQUE
(KEY:made clannad/angelbeats): Uniqueness=the ability to draw out a person's tears, its probably a company standard 4 every employee to come up with a sad anime : NOT SO UNIQUE BUT I LIKE IT.
Amagami: I hate this anime but w/e the 2-4 episode per heroine thing was pretty...UNIQUE
Pokemon: Really? do i have to say anything more? WHAT OTHER ANIME HAS...POKEMON IN IT. lol.
Ben-To: Really now? a whole anime based on fighting for half priced food, thats pretty out there.
Air Gear: been anime since i last saw this, (you no what? ima go watch it right now) A-Ts are creative yet, realistically possible, once we learn how to make flying pigs.
Baka to Test to Shoukanjuu: You have to do well in school to be able to fight well...WHY WOULD I WANT TO WATCH A ANIME ON DOING WELL IN SCHOOL!? Good thing the main characters an idiot like the rest of us and still get 2 hot chicks running after him
Eden of the East: do you no what i would do if i had a phone that could get me anything i wanted? (perverted smile)
The World Only God Knows: One of the best animes Com'on now, it nicely and clearly represents what everyone here on this forum does. xD
MM!: Oh...satisfying for all of us pervs. a M getting beat by a S as the mainstory...UNIQUE!
I'm 2 lazy 2 continue but i think every anime has that one point of uniqueness, why else is it an anime? Except for some animes like...half of the new animes 2day...stupid stuff O_O